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When the copper ion content is high in liver cells, the ATOX1 binds with excess copper ions and transports them to the N-terminal metal-binding region of ATP7B, which is then excreted through the bile duct membrane

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Such approaches may overcome the limitations of methods such as the spectral difference method, which assume the homogeneity of an image medium 73, 74

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This reduction leads to an increase in reactive oxygen species (ROS) like hydroxyl radicals, hydrogen peroxide, and superoxide ions