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Over the long history of the organism, the sequential or simultaneous conjunction in cells of many such dysfunctions may lead in one cell to a transition to complete independence: the tumor cell

The long-term effects can be partially predicted depending on the type of exposure, such as industrial pollutants [2,3] (e.g., diesel fumes), chemicals and toxic gases [35] (e.g., chlorine and mustard gas), occupational exposures [6,7] (e.g., asbestos, coal dust, silica), and recreational products such as tobacco smoke and electronic cigarette vapor [8]

This role of heavy metals in the causation of oxidative damage suggests that there is a not previously described mechanism involved in metal toxicity, thus prompting scientists to conduct investigations whether heavy metals are involved in the oxidative deterioration of biological macromolecules

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