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doi: 10.1016/S0014-5793(03)00277-1 186 SeidlS

Glutathione peroxidase (GPX) role in oxidative stress and its interaction with superoxide dismutase (SOD) The SOD gene locus resides on chromosome 21 and as a consequence of gene dosage excess, SOD activity has been shown to be increased by about 50% in all tissues of patients with Down syndrome (Brooksbank & Balzas, 1983

Dietary fit is where the split becomes obvious

The widespread use of herbicides causes oxidative stress in plants despite their weed control benefits

Notably, individuals at the extremes of age, both infants and the elderly, as well as those with pre-existing comorbidities, particularly cardiopulmonary disorders, are at markedly increased risk (490)