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While vitamin D deficiency has been consistently associated with alterations in gut microbiota composition, increased intestinal permeability, impaired immune tolerance, and increased susceptibility to infections and autoimmune conditions, evidence from interventional studies remains more variable

Sci Rep 14 , 28713 (2024)

Engelbart, S

230 As mentioned earlier, ROS accumulation and associated oxidative stress are important causes of mitochondrial dynamics alterations

Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]