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serve as a proof of how the gut microbiota can affect the pharmacokinetics of thiopurine drugs and may be the reason for interindividual variability in the therapeutic response ( Escherichia coli (Proteobacteria), Enterococcus faecalis (Firmicutes) and Bacteroides thetaiotaomicron (Bacteroidetes) ( Selection of Gut Bacterial SpeciesPotential Candidates Responsible for the Biotransformation of Azathioprine The chemical structure of certain drugs, in particular their functional groups (such as lactones, nitro, azo, sulfhydryl and urea groups), predispose these compounds for metabolic modifications by gut bacteria