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Res Mol Med

Preclinical evidence suggests gastroprotective and anti-inflammatory properties for BPC-157 [2]

doi: 10.1002/mds.26754 107 MajbourN

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Lipid Res 85 , 101139 (2022)

Keywords: autonomic nervous system, chronic pain, fatigue, near-infrared spectroscopy, fibromyalgia, magnetic resonance imaging, microcirculation, mitochondrial dysfunction, muscle oxygen saturation, physiological mechanisms, therapeutic strategies Introduction Fibromyalgia, recognized as a chronic syndrome distinguished by widespread musculoskeletal pain and significant fatigue, presents a complex clinical landscape that poses challenges to both patients and healthcare practitioners.1 The condition ensnares individuals within a labyrinth of diverse symptoms, encompassing sleep disturbances, autonomic dysfunctions, cognitive deficits, an exaggerated response to pain and other stimuli, somatic complaints, and concurrent psychiatric disorders.2,3 Among its hallmark features, widespread inflammation is prominently acknowledged in the literature as a pivotal factor exacerbating pain.4 This relationship establishes a pernicious cycle wherein increased pain discourages physical activity, leading to heightened sedentary behavior