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While considerable insight has been gained into the in vitro biochemical activity of Pol particularly in the context of exogenous DNA damageits physiological role in vivo remains poorly understood

Simple technique

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Classification and functional annotation of metabolites were performed based on the Human Metabolome Database (HMDB, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) database ( Partial least squares discrimination analysis (PLS-DA) was employed to identify differentially abundant metabolites between groups, utilizing the opls function with parameters orthoI=0 from the ropls R package (v1.34)