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FIGURE 2 Aging-associated increase in GSTM1 expression in the brain A recent study has reported that the expression level of GSTM1 in the hippocampus is associated with memory ability in 5xFAD mice, which harbors human mutations in the genes for amyloid precursor protein and presenilin one related to early-onset familial Alzheimers disease (Figure 3A)

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The optimisation of thiopurines is associated with increased rates of clinical and endoscopic remission [12, 13]