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Signal Transduct Target Ther (2021) 6(1):382

Long-term metabolic benefits of exenatide in mice are mediated solely via the known glucagon-like peptide 1 receptor

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Taking arginine metabolism as an example, myeloid cells in the tumor microenvironment, including tumor-associated macrophages and myeloid-derived suppressor cells, often suppress effector immunity through ARG1/ARG2-mediated arginine depletion