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Preclinical studies (animal models) were included specifically to elucidate molecular mechanisms not observable in human trials (e.g., histological bone changes or tissue-specific gene expression)

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Fivefold cross-validation further confirmed the robustness of our findings, with the ST-XGB model again exhibiting superior performance among the nine candidate combinations

For example, a recent meta-analysis reported an average AUROC of 0.88 for ML models, compared with the typical range of 0.740.77 for conventional scores

Staff et al., 2019