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Neh4 and Neh5 are also transactivation domains that bind to another transcriptional coactivator, CBP

The dipeptide cysteinylglycine is then degraded by a dipeptidase to produce cysteine and glycine

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These findings indicate that the peptides biological effects are not limited to pituitary GH secretion but may involve broader endocrine and metabolic pathways

This strategy ensures high specificity for glutathione-modified peptides while maintaining sensitivity across a broad dynamic range