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In vitro mechanistic studies also showed that the lead compound C1-27 acts as a slow-turnover substrate, though the significance of this mechanism is currently unclear

The products of Nrf2 target genes can be categorized into three broad groups (250)

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Experimental techniques that aim to reprogram glial cells into neurons or stimulate latent axonal growth pathways have yielded promising results in preclinical models

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The most frequent associations in HT are APS-2 and APS-3