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It works on both GLP-1 and GIP receptors and is commonly prescribed as part of medical weight loss programs

In states of obesity and aging, NNMT is often overexpressed, leading to the excessive methylation and excretion of nicotinamide

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(Wu et al., 2019) demonstrated in human umbilical vein ECs and arteries of HHcy mice that Hcy triggers the expression of ER oxidoreductin-1 (Ero1), leading to ER stress and subsequent inflammation

While tirzepatide does not directly target reproductive hormones, the significant weight loss and metabolic changes it produces can influence the hypothalamic-pituitary-ovarian axis that regulates menstruation

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