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[15] Maron BA, Loscalzo J

Chaudhary et al., 2022

More specifically, chenodeoxycholic acid and deoxycholic acid directly reduce ZO-1 and OCLN tight junction proteins and disrupt the BBB [234]

C., Brenes, M

Similar to the reduction in GSH-PX activity, the disruption of the PRX/Trx-mediated ROS scavenging through the depletion of Trx2 neonatal rat ventricular cardiomyocytes causes cardiomyocyte hypertrophy 10 , and mice with cardiomyocyte-specific deletion of Trx2 develop dilated cardiomyopathy with a severe decline in cardiac contractility and early mortality 11