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Heavy metal exposure has been associated with significant changes in liver histology and increased detoxification capacity

Curr Opin Clin Nutr 14(6):562568

Niacinamide, meanwhile, is generally considered safe but can cause mild burning sensation or redness in some people

Despite the impaired immune response in advanced age, persistence of the pro-inflammatory status results in a constant state of low-grade inflammation, characterized by the production of inflammatory mediators above basal levels [28]