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Of note, reports suggest that radiation and chemotherapy not only affect the stem cell pool, but also alter the neurogenic environment [reviewed in (40)]

Primary CLL/N M cells show enhanced metabolic performances To validate GSEA findings, we employed the Seahorse metabolic analyzer to measure both glycolysis and mitochondrial respiration, using the extracellular acidification rate (ECAR) and the oxygen consumption rate (OCR) as respective readouts

Sox11-modified mesenchymal stem cells accelerate cartilage defect repair in SD rats

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Practical readouts to separate signalling from damage Practical readouts to separate signalling from damage combine signalling proxiessuch as reversible cysteine oxidation mapped by redox proteomics, the redox state of peroxiredoxins as fast cycling sentinels, compartment-targeted H 2 O 2 reporters that resolve matrix/ER/PM microdomains and phospho-signatures downstream of redox-sensitive kinaseswith damage proxies including lipid-peroxidation adducts, protein carbonyls or nitrotyrosine, DNA oxidation and strand breaks and indices of bioenergetic failure (Garrido Ruiz et al