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Research demonstrates that TB-500 forms functional complexes with PINCH-1 and integrin-linked kinase (ILK) that can inhibit TNF--induced NF-B activation through blocking RelA/p65 translocation, providing rapid suppression of inflammatory transcriptional programs

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[DOI] [PubMed] [Google Scholar] 41.Wang C, Chen B, Feng Q, Nie C, Li T

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