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10.1016/j.neuroscience.2014.11.048 223 MorettoM

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The same was found in another study where increased lipid peroxidation and low-density lipoprotein oxidation were observed in the brains of hyperlipidemic mice and this was associated with increased activation of calpain-1/2 and MMP-2/9, and the downregulation of the TJs protein occludin in cerebral microvessels ( The intake of high doses of polyunsaturated fatty acids can promote lipid peroxidation and the subsequent propagation of oxygen radicals

Recently, using a rat model of optic nerve crush, it has been demonstrated that the primary factor mediating RGSs degeneration under these conditions is mobile zinc

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Xin et al found that the nuclear factor erythroid 2-related factor 2-heme oxygenase-1/glutathione peroxidase 4 axis in DM-associated ED rats was inhibited, leading to ferroptosis and oxidative stress, which impaired endothelial/smooth muscle cell function and further aggravated cavernous fibrosis [92]