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Briggs Kimberly J, Koivunen P, Cao S, Backus Keriann M, Olenchock Benjamin A, Patel H, Zhang Q, Signoretti S, Gerfen Gary J, Richardson Andrea L, Witkiewicz Agnieszka K, Cravatt Benjamin F, Clardy J, Kaelin William G

Garca-Gutirrez M, Prez-Ortiz J, Gutirrez-Adn A, Manzanares J (2010) Depression-resistant endophenotype in mice overexpressing cannabinoid CB2 receptors: depression and CB2r

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Based on this, an approach based on CAR-T cells has been developed to eliminate senescent cells

Mechanisms for this diversity include epigenetic changes, specifically methylation, of the genes encoding these receptors, multiple isoforms of each receptor as a consequence of alternative RNA splicing and multiple sites of translation initiation of receptor mRNA (Hirata et al., 2003

2000;2(4):665-671.[DOI] 77