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Moreover, BNIP3 and BNIP3L compete with Beclin-1 to bind to BCL2 and BCL-XL through their intrinsic BH3 atypical domain, resulting in disruption of the BCL2/BCL-XL-Beclin-1 complex and release of Beclin-1, which is required for autophagic activity [57]

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Kibbe, C., Chen, J., Xu, G., Jing, G

Histone deacetylase 4 promotes TGF-beta1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy

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