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Glutathione (GSH) is an antioxidant in plants, animals, fungi, and some bacteria and archaea

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Since MTX induces oxidative stress by increasing reactive oxygen species in tissues (Reference Jahovic, Cevik and Sehirli38,Reference Moghadam, Tutunchi and Namvaran-Abbas-Abad40,Reference Olayinka, Ore and Adeyemo43) , the effects of various antioxidant substances against MTX-induced oxidative stress have been investigated (Reference Savran, Cicek and Doguc7,Reference Jahovic, Cevik and Sehirli38,Reference Olayinka, Ore and Adeyemo43Reference Yuksel, Yuksel and Yagmurca45)

Antioxidant, chelating and HPLC quantification of phenols in extract of Phyllanthus niruri

A landmark 2007 study published in the Journal of Investigative Dermatology found that AHK-Cu at concentrations between 10 and 10 M stimulated dermal papilla cell (DPC) proliferation, elongated human hair follicles ex vivo, and shifted the Bcl-2/Bax ratio in favor of cell survival meaning fewer follicle cells died prematurely [2]