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During chronic oxidation stress there is a higher demand for the production of glutathione and thus, there is an increased demand placed on the methionine and transsulfuration pathways

2 Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

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In a separate study, a CRISPR KO screen in the GBM U138 cell line was performed with a sgRNA library consisting of 4,574 genes which targeted cell motility and trafficking