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*Correspondence: Anke Wagner, [email protected] This article was submitted to Synthetic Biology, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Although both the Cdc48/p97 ATPase complex and the proteasome recruit polyubiquitinated substrates, they employ distinct mechanisms