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NNMT normally burns through NAD+ precursors as a kind of metabolic "bleed." Block the bleed, and MOTS-C's expanded mitochondrial activity has more substrate to work with

it is the reverse

Full reconstitution guide Advanced calculator Dosing & Reconstitution Guide A single practical dilution with simple unit math, step by step Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Reconstitute: Add 3.0 mL bacteriostatic water to one 10 mg vial final concentration ~3.33 mg/mL

Two practical consequences fall out of this mechanism, and both explain the shape of the protocol below

The standard research protocol involves 300-500mcg daily

This strict protocol is critical because globally, 10-15% of untreated cases lead to neuropathy within just six months