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Description

In T2D, FA spillover from adipocytes increases hepatic acetyl-CoA, an allosteric regulator of pyruvate carboxylase activity, resulting in greater gluconeogenesis in the liver (183, 200)

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When activated by catecholamines like norepinephrine, they inhibit adenylyl cyclase, reducing cAMP and preventing fat breakdown

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PMID: 2 HorensteinALFainiACMorandiFOrtolanEStortiPGiulianiNet al

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