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Interestingly, our findings pinpointed that exposure to BaP significantly increased TNF-, IL-6, and IL-1 levels contrary to the control tilapia which is in line with a previous study investigated the immunotoxicity of BaP in olive flounder fish (Hur et al

However, it is important to note that Braaks theory remains unconfirmed, with some studies even contradicting it [126]

TCM herbs such as Salvia miltiorrhiza and Poria cocos modulate inflammation by regulating cytokine production and inhibiting NF-B activation, which leads to reduced inflammation and improved insulin sensitivity

[email protected] Li, [email protected] These authors have contributed equally to this work This article was submitted to Cellular and Molecular Mechanisms of Brain-aging, a section of the journal Frontiers in Aging Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The results were also confirmed by the CLSM images (Fig