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Der Mechanismus umfasst die Anziehung von Immunzellen und mesenchymalen Stammzellen zum Wundgebiet sowie die Stimulation der Glykosaminoglykan- und Decorin-Synthese, die beide fr eine ordnungsgeme Extrazellulrmatrix-Assemblierung entscheidend sind

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The varieties of consequent enzymatic dysfunction resulting from these mutations include impaired binding of substrate and cofactor to the isozyme, blocked formation of a functional isozyme (deletion, nonsense mutation, or splice-junction alterations), and an unstable isozyme resulting in DHT deficiency due to a decreased conversion of testosterone to DHT (5)

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