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enrolled 224 HCV-2 and HCV-3 patients, and evaluated PEG-IFN plus RBV administered for 24 weeks and noted higher rates of SVR in HCV-2 patients (93%) than in those with HCV-3 (79%).[53] These results were confirmed in a subsequent meta-analysis: 74% in HCV-2 in comparison with 69% in HCV-3.[54]The presence of steatohepatitis and more advanced fibrosis in HCV-3 could contribute to poorer therapeutic response in these patients.[55, 56] Shah et al

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Factors such as the severity of VAD, the presence of concomitant ID, and individual variations in response to supplementation may contribute to the variability observed in these studies

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