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269,270 An imbalance between mitochondrial biogenesis and fission leads to the formation of small, dysfunctional mitochondria, affecting both neurons and Schwann cells and exacerbating peripheral nerve damage

All of this can contribute to the deceleration of mental decline

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This creates a vicious cycle: viral inflammation depletes antioxidants, genetic bottlenecks prevent the synthesis of new antioxidants, and the resulting oxidative stress causes the mitochondria to shut down ATP production, leading to the debilitating fatigue that characterizes ME/CFS and Long COVID