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GEORGE KARELIAS AND SONS EXCELLENCE Application Number 004773677 Status Registered Filing Date 2005-12-01 Registration Date 2006-10-10 Owner KARELIA TOBACCO COMPANY INC (Greece) NICE Classes

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Disruptions in SNX1 and the core retromer component VPS29 impair formation of the spherical vesicles near MVBs, lead to the development of enlarged MVBs, and result in embryonic lethality before the globular stage