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56 As the disease progresses, defects in fatty acid oxidation due to the repression of transcription factors, such as sterol regulatory element-binding proteins and peroxisome proliferator-activated receptor-, result in energy depletion and the release of mitochondrial RNA/DNA, activating inflammatory pathways involving interferon regulatory transcription factor and transforming growth factor-beta (TGF-)

These findings indicate that the increased translocation of LPS from gut-commensal gram-negative bacteria is due to increased intestinal permeability (or a leaky gut)

[DOI] [PubMed] [Google Scholar] 38.Scalise M., Galluccio M., Console L., Pochini L., Indiveri C

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Norat P, Soldozy S, Sokolowski JD, Gorick CM, Kumar JS, Chae Y, et al