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Since many metabolites of phase I are too lipophilic to be retained in the kidney tubules, a subsequent conjugation reaction with an endogenous substrate, such as glucuronic acid, acetic acid, sulfuric acid or an amino acid, results in formation of more polar and hydrophilic compounds that are sufficiently polar to be excreted by the kidneys

Fourth, regulatory requirements

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However, most of these studies were performed in the absence of HGF, excluding the fact that HGF is generally present in the tumor and its microenvironment