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Heat stress may lead to changes in oocyte membrane properties, such as decreased phospholipid polyunsaturated fatty acid contents 10 , which are essential for gamete fertility 11

Understanding this balance provides critical insights into tumor biology and opens new avenues for the development of anti-angiogenic therapies aimed at improving patient outcomes in GI cancers ( 3 Vascular disruption strategies 3.1 Molecular mechanisms of vascular disruption The molecular mechanisms underlying vascular disruption are complex and multifaceted, primarily involving the regulation of angiogenesis, which is the formation of new blood vessels from pre-existing ones

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The resulting buildup of damaged organelles and undegraded material increases intracellular stress, generating ROS and releasing DAMPs

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It is overexpressed also in activated endothelial cells, new-born vessels, and various other tumor cells but is not found in most adult epithelial cells (Cai and Chen, 2006