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The SP formulation (4 mg/mL) allows for administration of relatively large doses in a small volume of diluant because it is highly water soluble

In addition, increased BID S66 phosphorylation is required to induce apoptosis of cells stalled at the mitotic checkpoint, with a non-phosphorylatable form of BID suppressing cell death following mitotic arrest (Wang et al., 2014)

PMID 12749025

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For example, molecular docking can predict receptor-ligand interactions, whereas molecular dynamics (MD) simulation can refine drug structures, validate docking results, and assess ligand binding dynamics at atomic level 43