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Collective findings from these studies underscore persistent translational challenges, including size heterogeneity, rapid renal clearance, and limited long-term toxicological data, highlighting the need for improved targeting, surface modification, and synthesis control to support clinical translation [91, 190]

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CONQUER demonstrated body weight reduction from baseline of 10.2%, and 7.8%, with high (15/92 mg), and medium (7.50/46.0 mg), doses of PHEN/TPM, respectively, (vs