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The main objective of the therapy is to suppress the synthesis of melanin, which may lead to a lighter and more uniform skin complexion

Research has explored its effects on matrix metalloproteinase regulation, dermal fibroblast activity, and anti-inflammatory cytokine modulation in cell culture models

These may include nausea, reduced appetite, vomiting, diarrhea, constipation, abdominal discomfort, or reflux

Clinical Principle The clinical diagnosis of IC/BPS requires a careful history, physical examination, and laboratory examination to document basic symptoms that characterize the disorder and exclude infections and other disorders (see Figure 1: IC/BPS Diagnostic and Treatment Algorithm)

Folate-deficiencyinduced homocysteinaemia in rats: Disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism