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Studies have also noted that individuals with particular SNPs affecting B12 absorption may improve their B12 levels more efficiently by taking one or more active forms of the nutrient

Neuroscience (2013) 234:14657

doi:10.1016/j.fertnstert.2013.08.032

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In DPPOS year 9, vitamin B 12 deficiency rates were 4.4%, 5.9%, and 4.9% for GG, AG and AA genotype groups in the placebo arm, vs 5.7%, 6.6%, and 18.7% in those respective genotype groups in the metformin arm (ESM Table 9)