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10.1007/s00381-010-1300-1 37 NiimuraM.TakagiN.TakagiK.FunakoshiH.NakamuraT.TakeoS

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however the phylogenetic distribution of the metazoan TrxR appears to be similar to the predicted phylogenetic distribution of an NADPH-independent disulfide reductase system (see below)

In cells, homocysteine is metabolized in three ways :[ref] It can be remethylated to form methionine (requires folate, MTHFR, and vitamin B12, MTR gene or needs betaine, interacting with BHMT and PEMT genes) Can be converted to cysteine (CBS gene, serine and B6 as a cofactor), which is used in the synthesis of glutathione It can be converted to homocysteine thiolactone, which can be a problem at higher levels Lets dig into each of these pathways further: Methylation Cycle: Homocysteine, Methionine, SAMe, and SAH Homocysteine is maintained at a relatively constant level by several mechanisms in the methionine cycle