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One such mechanism may be 1C metabolism that drives the de novo synthesis of purine nucleotides (e.g., AMP), suggesting that de novo biosynthesis of purine nucleotides, which is based on the metabolism of 1C compounds, is a new target for metformins actions in ageing

Wang ML , Jurczak W, Zinzani PL, Eyre TA, Cheah CY, Ujjani CS, Koh Y, Izutsu K, Gerson JN, Flinn I, Tessoulin B, Alencar AJ, Ma S, Lewis D, Lech-Maranda E, Rhodes J, Patel K, Maddocks K, Lamanna N, Wang Y, Tam CS, Munir T, Nagai H, Hernandez-Ilizaliturri F, Kumar A, Fenske TS, Seymour JF, Zelenetz AD, Nair B, Tsai DE, Balbas M, Walgren RA, Abada P, Wang C, Zhao J, Mato AR, Shah NN Pirtobrutinib in Covalent BTK-Inhibitor Pre-treated Mantle Cell Lymphoma

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Often paired with BPC in what is commonly called a recovery stack

doi: 10.1038/nm.4407 141 LiuXOlszewskiKZhangYLimEWShiJZhangXet al