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Induction of SIRT1 by melatonin improves alcohol-mediated oxidative liver injury by disrupting the CRBN-YY1-CYP2E1 signaling pathway

[6] [10] The correct tier is therefore investigational, development halted for lack of demonstrated efficacy not approved, and emphatically not a compound that succeeded in trials

doi: 10.3389/fphar.2023.1254382 Received 07 July 2023 Accepted 31 August 2023 Published 08 September 2023 Volume 14 - 2023 Edited by Marzia Soligo, National Research Council (CNR), Italy Reviewed by Vikas Mishra, Babasaheb Bhimrao Ambedkar University, India Diego Iacono, Uniformed Services University of the Health Sciences (USU), United States Updates Copyright 2023 Hiskens, Li, Schneiders and Fenning