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Moreover, AP in 28 days had an increase in alveolar bone resorption compared to apical periodontitis in 14 days (13.17 1.10 vs

doi: 10.3389/fphys.2021.627837 30 ForresterSJKikuchiDSHernandesMSXuQGriendlingKK

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The ominous octet (Defronzo model) includes: decreased muscle glucose uptake, increased hepatic glucose output, impaired incretin effect, alpha-cell hyperglucagonemia, increased renal glucose reabsorption (SGLT-2 upregulation), increased lipolysis (adipose), decreased central satiety signaling, and decreased beta-cell insulin secretion