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4MO, a substantial accumulation of metastatic nodules within the lungs was observed in the control group, whereas CUR administration (CUR@Bio/PE-NPs) demonstrated an obvious reduction

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doi: 10.1016/j.biomaterials.2013.04.064

According to clinicians, sublingual administration bypasses both the gut and the liver, allowing glutathione to enter the bloodstream in its reduced (active) form, boosting the ratio of GSH to GSSG by 230 per cent, whereas oral glutathione supplementation is either reduced into simple amino acids during digestion or oxidised and hence, no longer stays active when swallowed

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Persistent higher activity (neuronal excitation) caused by chronically increased extracellular glutamate, combined with higher metabolic/energy needs, could then produce a critical state potentially resulting in neuronal death