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Tumor necrosis factor (TNF) is a core inflammatory factor in RA, which inhibits phosphatase and tensin homologue-induced kinase 1 (PINK1)-mediated mitophagy and elicits mitochondrial damage, which increases cytoplasmic mtDNA levels and activates cGAS-STING, boosting inflammation in RA (105) (Figure 2)

Furthermore, Acsm3 knockout mice showed glucose and lipid metabolic abnormalities, and hepatic accumulation of the ACSM3 fatty acid substrate lauric acid

Individual Factors Finally, its important to note that individual factors such as skin type, overall health, and lifestyle can influence the efficacy of glutathione for skin lightening

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Self-assembled EGCG nanoparticles with enhanced intracellular ROS scavenging for skin radioprotection

Cheng C-F, Ku H-C, Lin H (2018) PGC-1 as a Pivotal Factor in Lipid and Metabolic Regulation