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& Otto, S

It functions as a direct antioxidant through its thiol group, a substrate for glutathione peroxidase and glutathione S-transferase enzymes, and a regulator of protein function through S-glutathionylation

doi: 10.1016/j.psychres.2023.115172 88 YangH.ZhangZ

Given that Glu is primarily neuroactive while Gln is storable and neuroinactive, the Gln/Glu ratio can reflect the efficiency of Glu uptake by astrocytes and its conversion to Gln, which is crucial for regulating excitatory neurotransmission [20]

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Conclusion: These data strongly suggest that the dysbiotic microflora characterized by a decrease in butyrate producing bacteria plays a causal role in MDB formation and pathogenesis of AAH