l-carnitine fatty acid metabolism A schematic diagram of the metabolic roles of carnitine in skeletal Carnitine in Mitochondrial Fatty Acid

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Conflict of interest The authors declare no competing interests

Patients with Mitochondrial Disease: There is an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes caused by DNA mutations of the mitochondrial DNA Polymerase (POLG) gene (e.g., Alpers-Huttenlocher Syndrome)