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10.1016/j.addr.2019.04.008 52 DuranN.SilveiraC

Patriarca, S., Furfaro, A

Freezing a reconstituted peptide solution causes ice crystal formation, which exerts mechanical shear forces on the peptide structure and can disrupt hydrogen bonding that maintains tertiary conformation

This review underscores the potential benefits of melatonin as a supplementary treatment for neurodegenerative disorders in older adults, stressing the necessity for additional studies to confirm its efficacy and standardize its use in treatment plans