PSEN1 is one of four core proteins in the -secretase endoprotease complex that performs intramembrane cleavage of dozens of integral membrane proteins, including -amyloid precursor protein (APP) that sequentially generates the -carboxy-terminal fragment (CTF) and amyloid-, two polypeptides implicated in AD pathogenesis Ryanodine receptors (RyRs) Ion channels residing in the sarcoplasmic/endoplasmic reticulum membrane and responsible for Ca 2+ release from intracellular stores in excitable tissues, such as muscles and neurons Tau (MAPT) A group of six highly soluble protein isoforms produced by alternative splicing from MAPT that help stabilize the microtubule cytoskeleton of neurons and compose neurofibrillary tangles, a hallmark of Alzheimer disease (AD) TFEB, TFE3 Members of the MiT-TFE family of helixloophelix leucine zipper transcription factors that regulate expression of genes involved in the biogenesis and function of lysosomes and autophagosomes Footnotes Competing interests D.C.R
Based on the preliminary results, we repeated the study with nine additional animals and found that four exhibited a similar trend of co-infection
Testing pathological variation of white matter tract in adult rats after severe spinal cord injury with MRI
As sex-associated differences were observed for isoenzyme-specific substrates in liver [39, 41], we cannot rule out that certain GST isoenzymes are differently expressed in choroid plexuses between male and female animals
Carnitine serves a second critical metabolic function, buffering the Coenzyme A pool against accumulation of short chain acetyl-CoAs, which at increasing levels reduce the activity of the pyuvate dehydrogenase complex (PDC)
Prolonged Administration of Arsenic Trioxide (Trisenox) for Patients with Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML) at MD Anderson Cancer Center: A Phase II Study
