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Nothapodytes foetida is recognized for its richness in camptothecin (CPT), a water-immiscible terpenoid indole alkaloid that can substantially suppress DNA topoisomerase I, a crucial enzyme for modulating the topology of DNA by releasing/relaxing DNA supercoiling during DNA replication [257]

Upon full equilibration of the sensor with the surrounding glutathione pool E GSH can be calculated from OxD as follows: E roGFP2 =280 mV (Dooley et al , 2004)