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Hamida, R

In addition, animal experiments and cell experiments have confirmed that berberine reduces the levels of extracellular and intracellular A, increases the levels of LC3-II, Beclin-1, hVps34 and cathepsin-D, and reduced the levels of P62, Bcl-2, amyloid precursor protein (APP), and beta-secretase 1 (BACE1)

Hence, the role of YRS in GC may depend on its localization, wherein its secreted form promotes tumor progression while the nuclear YRS played a protective role

The mitochondrial response to DNA damage

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This causes tumor necrosis factor-like weak inducer of apoptosis (TWEAK) to demonstrate its pro-atherosclerotic tendency ( IL1B )