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Key phytochemicals including polyphenols (flavonoids, phenolic acids such as curcumin, resveratrol, and EGCG), carotenoids (lycopene, lutein), and organosulfur compounds demonstrate potent free radical scavenging capacity, regulate antioxidant enzyme activity, and inhibit lipid peroxidation through Nrf2 pathway activation and NF-B inhibition

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EPIDEMIOLOGY Human liver fluke infections are endemic in Eurasia, with at least 680 million people at risk of infection according to estimates published in 2005 (22)